A randomized and controlled study of the effect of Echinacea Purpurea on canine Parvovirus and Distemper Virus antibody levels in dogs
Item
Title
A randomized and controlled study of the effect of Echinacea Purpurea on canine Parvovirus and Distemper Virus antibody levels in dogs
Description
Am J Trad Chin Vet Med (2018), Yucheng Guan;Jiuzhi Chen;Shanshan Zhou;Cui Liu;Dayou Shi
Journal Publication
issn
1945-7693
Date
Language
English
Abstract
The objective of this randomized, controlled study was to investigate the immunomodulating effects of a root preparation of Echinacea purpurea (EP) on canine parvovirus (CPV) and canine distemper virus (CDV) vaccination in dogs. Twenty-five healthy young poodles were randomly divided into 5 groups consisting of 5 dogs per group. All dogs were vaccinated with a modified live virus and observed for 3 days for adverse effects. Dogs in the experimental groups (groups 1-4) then received a daily oral preparation of EP dosed at 0.1g/kg, 0.2g/kg, 0.4g/kg, or 0.8g/kg with the fifth group of dogs remaining as untreated controls. After administering EP for 21 days, an additional 7-day observation period was conducted thus providing a total of 28 days on study. The serum antibody titers to CPV and CDV were determined by enzyme-linked immunosorbent assay (ELISA) on days 7, 14, 21 and 28 and results analyzed by one-way analysis of variance (ANOVA). Results showed that the antibody titers significantly increased after oral administration of EP in a dose dependent manner with dogs given 0.8g/kg (Group 4) demonstrating the greatest effect with statistically significant CPV and CDV antibody increases at all timepoints. The results of this experiment indicate that EP could be used as an immune enhancement agent for CPV and CDV vaccination in dogs.
volume
13
issue
2
Abbreviated Journal Title
Am J Trad Chin Vet Med
page start
13
page end
18