The effectiveness of integrating gui pi tang with conventional medicine in the treatment of thrombocytopenia in dogs: a retrospective study
Item
Title
The effectiveness of integrating gui pi tang with conventional medicine in the treatment of thrombocytopenia in dogs: a retrospective study
Description
Am J Trad Chin Vet Med (2020), Wong, Chee May; Shiau, Deng-Shan.
Abstract
The objective of this retrospective study was to determine the efficacy of an integrative treatment regime that combines the Chinese herbal medicine, Gui Pi Tang (GPT), with and antibiotic (doxycycline) with or without vitamin K1 for treating dogs with thrombocytopenia. The study was carried out on medical records of dogs with a platelet count (PL) less than the normal range of 200x10E9/L. Among the 74 subjects, there were four groups; (Group A) treated with GPT + doxycycline; (Group B) treated with GPT + doxycycline + vitamin K1 injection; (Group C) treated only with doxycyline; (Group D) treated with doxycyline + vitamin K1. there were 8 study assessment time points: Week 0 (baseline) through Year 3. Statistical comparisons focused on improvements in PL (mean platelet increase, recovery rate). Except for Week 1, Group (A+B/GPT treatment) had significantly greater PL improvements (p<0.001) at all study assessment timepoints than those in (C+D/non-GPT treatment). With respect to the PL recovery rate, subjects in group (A+B) had 74.2% of the study dogs recover to normal PL reference range by Month 1 and 89.5% by Year 3; whereas group (C+D) had recovery rates of 21.4% and 31.3% for Month 1 and Year 3, respectively. these differences were statistically significant from Month 1 through Year 3 (p≤0.001). Gui Pi tang demonstrated equal statistically significant efficacy in treating thrombocytopenia associated with blood borne parasitic infection or idiopathic immune-mediated disease. Results from this retrospective study suggest that integrating GPT with doxycycline was more effective for treating canine thromboctopenia that doxycycline alone.
Alternative Title
Am J Trad Chin Vet Med
Creator
Date
Language
English
issn
1945-7677
issue
2
page end
52
page start
39
volume
15