Regulation of acupuncture on NMDAR1 mRNA expression in visual cortex of monocularly-deprived rats
Item
Title
Regulation of acupuncture on NMDAR1 mRNA expression in visual cortex of monocularly-deprived rats
Description
J Acupunct Tuina Sci (2017), Zhu Tian-tian;Chen Cheng;Tan Xing-ke.
Abstract
Our previous work showed that acupuncture therapy had significant efficacy on amblyopia, and could effectively antagonize the deprivation efffect on the visual development in the sensitive period. The mechanism may be related to promoting the brain-derived neurotrophic factor, brain derived nerophic factor (BDNF) and N-methyl-D-aspartate receptor (NMDAR) synthesis, secretion and gene expression in visual system. In this study, visual electrophysiology and reverse transcription polymerase chain reaction (RT-PCR) were used to investigate the effect of acupuncture, based on years of clinical experience in point selection, by focusing on the mRNA expression of visual pattern visual evoked potential (P-VEP) and NMDAR1 (synaptic development-related receptors of viusal cortex neurons). The possible molecular mechanism of acupuncture for monocularly-deprived amblyopia in rat models in the sensitive time period was explored.
Alternative Title
J Acupunct Tuina Sci
Creator
Date
Date Created
12/1/2018
Language
English|Chinese
Type
Journal Article
issn
1672-3597
issue
1
page end
7
page start
1
volume
15