Effects of electroacupuncture plus dopamine D1 receptor antagonist on somatosensory evoked potentials and behavioral changes in rats with cerebral ischemia-reperfusion
Item
Title
Effects of electroacupuncture plus dopamine D1 receptor antagonist on somatosensory evoked potentials and behavioral changes in rats with cerebral ischemia-reperfusion
Description
J Acupunct Tuina Sci (2012), Cheng-yong, Liu
Abstract
Objective: To explore the effects of electroacupuncture (EA) plus dopamine D1 receptor (D1R) antagonist on somatosensory evoked potentials (SEP) and behavioral changes in rats with cerebral ischemia-reperfusion. Methods: Forty rats were randomly divided into a normal group, a model group, an EA group, a D1R antagonist group and an EA+D1R antagonist group, with 8 rats in each group. Ischemia-reperfusion model was established in the other 4 groups except the normal group, and they were treated by different ways after modeling successfully. SEP, neural function defect score (NFDS) and beam walking tests were performed before and after modeling, before sacrifice respectively. Results: SEP of the EA group, D1R antagonist group and EA+D1R antagonist group showed significant differences when compared with that of the model group (P<0.05) after treatment. Before treatment, behavioral tests of the model group showed significant decreases compared with those of the normal group (P<0.05). After treatment, behavioral tests in the EA group, the D1R antagonist group and the EA+D1R antagonist group improved obviously and showed statistical differences compared with those in the model group (P<0.05). Conclusion: EA and D1R antagonist treatments could both promote the neural functional recovery after ischemia-reperfusion and play a brain-protective role, but there was no synergistic effect of EA and D1R antagonist in combination.
Alternative Title
J Acupunct Tuina Sci
Creator
Date
Language
English
Subject
issn
1672-3597
issue
3
page end
137
page start
133
volume
10