Regulating effect of moxibustion on MCP-1 and NF-kB in the colonic mucosa tissue of rats with Crohn's disease
Item
Title
Regulating effect of moxibustion on MCP-1 and NF-kB in the colonic mucosa tissue of rats with Crohn's disease
Description
W J Acupunct Moxi (2016), Zhang Hui;Zhou Shuang;Song Xiao-ge;Xu Wen-fei;Li Ling-xiu;Su San-shan;Hu Yang-chun;Li Zhen-feng;Zhang Li;Xie Ming-yue.
Abstract
To observe the effect of moxibustion on the expression levels of MCP-1 and NF-kB proteins in the colonic mucosa tissue of rats with Crohn's disease (CD). Morris method, which is internationally recognized, was adopted to establish CD rat models. The rats were randomly divided into blank control group, CD model group, and moxa stick moxibustion group. In the moxa stick moxibustion group, the cigarette-like moxa sticks were used for suspended moxibustion at the locations 2 cm from Pishu (BL 20) and Zhongwan (CV 12). The treatment was conducted once a day, lasted for 20 min at each time, and 7 times were needed; one acupoint was used for each time, and the two acupoints were used alternately. Under light microscope, HE staining was used to observe the pathological changes of colon, and immunohistochemical method was adopted to observe the expression levels of MCP-1, NF-kB p 65 and NF-kB p 50 proteins in colonic mucosa tissue of rats.
Alternative Title
W J Acupunct Moxi
Creator
Date
Date Created
6/5/2018
Language
English
Subject
Type
Journal Article
issn
1003-5257
issue
4
page end
40
page start
33
volume
26