Influence of moxibustion at ''Shenshu'' (BL 23) and ''Zusanli (ST 36) on Ras-MAPK signal pathways in synovial tissues of rats with experimental rheumatoid arthritis
Item
Title
Influence of moxibustion at ''Shenshu'' (BL 23) and ''Zusanli (ST 36) on Ras-MAPK signal pathways in synovial tissues of rats with experimental rheumatoid arthritis
Description
W J Acupunct Moxi (2013), Yao, Jian;Hu, Ling;Song, Xiao-ge .
Abstract
To observe influence of moxibustion at “Shenshu” ( BL 23) and “Zusan” ( ST 36) on proteins expression of Ras, ERK1/2, and Raf in synovial tissues in rats with rheumatoid arthritis (RA) to elucidate molecular mechanisms of moxibustion on treating RA. Methods: Thirty Wistar rats were randomly divided into a normal control group (Group Cont), a model group (Group Mod) and a moxibustion group (Group Mox) with 10 rats in each group. The model was established by using both environmental factors such as wind, cold and damp and a biological factor (Freund's complete adjuvant). Suspended moxibustion was applied at bilateral BL 23 and ST 36 for 20 min, applied once daily for 15 days, starting from the 3rd day after modeling. Volumes of metaleg digiti pedis on the right side were measured before, after and 15 days after modeling. Protein expressions of Ras, ERK 1/2, p-ERK1/2 and Raf in synovium tissues were detected by western blot.
Alternative Title
W J Acupunct Moxi
Creator
Date
Date Created
6/14/2014
Language
Chinese
Subject
Type
Journal Article
doi
http://dx.doi.org/10.1016/S1003-5257(13)60040-9
issn
1003-5257
issue
2
page end
33
page start
29
volume
23